Polyoxometalate-based heterojunction with NIR light-facilitated photocatalytic W6+/W5+ redox cycling for enhanced bacteria-infected wound healing

Metal-based nanomaterials with shifting or mixed redox states have been widely applied for combating against bacteria-infected diseases by virtue of their peroxidase (POD)-like catalytic activity. Herein, a polyoxometalate-based heterojunction (GdP5W30@WS2) (W6+/W5+) is devised to achieve boosted reactive oxygen species (ROS) generation near-infrared (NIR) laser-facilitated W6+/W5+ cycling accelerated wound healing. On the one hand, under exposure NIR laser, WS2 as electron donor could be stimulated transfer electrons GdP5W30, which promotes reduction from W6+ W5+ active sites on surface GdP5W30. Consequently, regenerated catalyze endogenous overexpressed H2O2 persistently generate ROS, displays enhanced POD-like activity chemodynamic therapy (CDT) NIR-driven photocatalytic cycling. Moreover, GdP5W30@WS2 also favorable glutathione (GSH)-activated photothermal performance W6+-triggered GSH exhaustion sufficient ROS generation, thereby facilitating synergistic therapeutic efficiency (PTT) and CDT. We expect that present work will promote development biofilm elimination based NIR-facilitated enzyme-like activity, may act candidate BME-activated therapy.